Assay Detail
Functional
CHEMBL958391
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Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses of novel high affinity ligands for opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.06 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511645 | — | — | 1 | 9.07 |
| CHEMBL471048 | — | — | 1 | 8.80 |
| CHEMBL398707 | HYDROMORPHONE | 4.0 | 1 | 8.59 |
| CHEMBL512150 | — | — | 1 | 8.51 |
| CHEMBL56695 | — | — | 1 | 8.31 |
| CHEMBL470005 | — | — | 1 | 8.00 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.80 |
| CHEMBL895 | NALBUPHINE | 4.0 | 1 | 7.34 |
| CHEMBL38874 | DAMGO | — | 1 | 7.26 |
| CHEMBL471049 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511645 | — | EC50 | = | 0.86 | nM | 9.07 |
| CHEMBL471048 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL398707 | HYDROMORPHONE | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL512150 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL56695 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL470005 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL19019 | NALTREXONE | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL895 | NALBUPHINE | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL38874 | DAMGO | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL471049 | — | EC50 | = | 110.0 | nM | 6.96 |