Assay Detail
Binding
CHEMBL955069
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Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses of novel high affinity ligands for opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 9.05 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471243 | — | — | 1 | 10.28 |
| CHEMBL511645 | — | — | 1 | 10.14 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.96 |
| CHEMBL470005 | — | — | 1 | 9.80 |
| CHEMBL511816 | — | — | 1 | 9.62 |
| CHEMBL398707 | HYDROMORPHONE | 4.0 | 1 | 9.55 |
| CHEMBL471048 | — | — | 1 | 9.52 |
| CHEMBL469815 | — | — | 1 | 9.29 |
| CHEMBL512150 | — | — | 1 | 9.28 |
| CHEMBL56695 | — | — | 1 | 9.15 |
| CHEMBL471049 | — | — | 1 | 8.92 |
| CHEMBL511302 | — | — | 1 | 8.89 |
| CHEMBL895 | NALBUPHINE | 4.0 | 1 | 8.80 |
| CHEMBL470617 | NALTREXONE METHIODIDE | — | 1 | 8.70 |
| CHEMBL511621 | — | — | 1 | 8.60 |
| CHEMBL513762 | — | — | 1 | 8.42 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 8.28 |
| CHEMBL511461 | — | — | 1 | 7.43 |
| CHEMBL511795 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471243 | — | Ki | = | 0.052 | nM | 10.28 |
| CHEMBL511645 | — | Ki | = | 0.072 | nM | 10.14 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL470005 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL511816 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL398707 | HYDROMORPHONE | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL471048 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL469815 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL512150 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL56695 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL471049 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL511302 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL895 | NALBUPHINE | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL470617 | NALTREXONE METHIODIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL511621 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL513762 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL511461 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL511795 | — | Ki | = | 46.0 | nM | 7.34 |