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Compound Detail

CHEMBL2138684

FROVATRIPTAN SUCCINATE
💊 Approved Drug
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💊 Approved Drug
CN[C@@H]1CCc2[nH]c3ccc(C(N)=O)cc3c2C1.O.O=C(O)CCC(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2138684
Name FROVATRIPTAN SUCCINATE
Phase Approved
Structure Type MOL
InChI Key CUETXFMONOSVJA-KLQYNRQASA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL1279
Active Moiety CHEMBL1279

Known Names

Frova Frovatriptan succinate Frovatriptan succinate hydrate Frovatriptan succinate monohydrate Frovelan Miguard NSC-760422 SB 209509 AX SB 209509-AX SB-209509-AX SB-209509AX VML 251 +1 more
8
Targets
8
Activities
1
Assay Types
0
PK Parameters
20
Publications
13
Known Names
1
Indications
2
Mechanisms

Molecular Properties

243.3
MW (Da)
1.34
ALogP
2
HBA
3
HBD
70.9
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2001
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral
USAN Stem -triptan
USAN Year 1997

Extended Properties

Molecular Formula C18H25N3O6
MW 379.41
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -0.45

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Serotonin 1b (5-HT1b) receptor agonist AGONIST 5-hydroxytryptamine receptor 1B ✓ ✓
Serotonin 1d (5-HT1d) receptor agonist AGONIST 5-hydroxytryptamine receptor 1D ✓ ✓

Indications

Migraine Disorders

Activity Summary

Ki 8 meas. best 7.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1B
CHEMBL1898
 Ki 7.64 7.64 22.9 1
5-hydroxytryptamine receptor 7
CHEMBL3155
 Ki 7.44 7.44 36.0 1
Mu-type opioid receptor
CHEMBL233
 Ki 6.73 6.73 187.0 1
5-hydroxytryptamine receptor 1E
CHEMBL2182
 Ki 6.51 6.51 310.7 1
D(2) dopamine receptor
CHEMBL217
 Ki 6.16 6.16 694.2 1
D(4) dopamine receptor
CHEMBL219
 Ki 6.04 6.04 909.0 1
5-hydroxytryptamine receptor 1A
CHEMBL214
 Ki 5.83 5.83 1472.0 1
Sigma intracellular receptor 2
CHEMBL4105907
 Ki 5.49 5.49 3255.4 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
5-hydroxytryptamine receptor 1B Ki = 22.87 nM 7.64 PDSP Secondary Binding target: HTR1B - Compounds are tested at 10 uM concentrati... -
5-hydroxytryptamine receptor 7 Ki = 36.05 nM 7.44 PDSP Secondary Binding target: HTR7 - Compounds are tested at 10 uM concentratio... -
Mu-type opioid receptor Ki = 186.98 nM 6.73 PDSP Secondary Binding target: OPRM1 - Compounds are tested at 10 uM concentrati... -
5-hydroxytryptamine receptor 1E Ki = 310.74 nM 6.51 PDSP Secondary Binding target: HTR1E - Compounds are tested at 10 uM concentrati... -
D(2) dopamine receptor Ki = 694.23 nM 6.16 PDSP Secondary Binding target: DRD2 - Compounds are tested at 10 uM concentratio... -
D(4) dopamine receptor Ki = 908.97 nM 6.04 PDSP Secondary Binding target: DRD4 - Compounds are tested at 10 uM concentratio... -
5-hydroxytryptamine receptor 1A Ki = 1471.97 nM 5.83 PDSP Secondary Binding target: HTR1A - Compounds are tested at 10 uM concentrati... -
Sigma intracellular receptor 2 Ki = 3255.37 nM 5.49 PDSP Secondary Binding target: TMEM97 - Compounds are tested at 10 uM concentrat... -

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL5058564 HEK-293T 6
- 10.6019/CHEMBL5058564 U2OS 6
- 10.6019/CHEMBL5058564 Fibroblast 3
- 10.6019/CHEMBL5209801 N-formyl peptide receptor 2 2
- 10.6019/CHEMBL5209801 C5a anaphylatoxin chemotactic receptor 1 2
- 10.6019/CHEMBL5209801 Sphingosine 1-phosphate receptor 1 2
- 10.6019/CHEMBL5209801 Alpha-2A adrenergic receptor 2
- 10.6019/CHEMBL5209801 Glucose-dependent insulinotropic receptor 2
- 10.6019/CHEMBL5209801 CX3C chemokine receptor 1 2
- 10.6019/CHEMBL5209801 Apelin receptor 2
- 10.6019/CHEMBL5209801 Free fatty acid receptor 4 2
- 10.6019/CHEMBL5209801 Type-1 angiotensin II receptor 2
- 10.6019/CHEMBL5209801 Beta-2 adrenergic receptor 2
- 10.6019/CHEMBL5209801 Adhesion G-protein coupled receptor F1 2
- 10.6019/CHEMBL5209801 Glucagon-like peptide 1 receptor 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL5209801 G-protein coupled receptor 35 2
- 10.6019/CHEMBL5665443 Uracil-DNA glycosylase 1
- 10.6019/CHEMBL5060014 Fibroblast growth factor receptor 3 1
- 10.6019/CHEMBL5060014 Casein kinase I isoform delta 1

Data from ChEMBL 36 via Core Engine