5-hydroxytryptamine receptor 1E · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P28566. Use UniProt P28566 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28566 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 1E
Review this target as 5-hydroxytryptamine receptor 1E, mapped to UniProt P28566. Sequence length is 365 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 1E as ChEMBL target CHEMBL2182, mapped to UniProt P28566. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-hydroxytryptamine receptor 1E is the right protein anchor across sources, using UniProt P28566 as the stable mapping.
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| Preferred Name | 5-hydroxytryptamine receptor 1E |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P28566 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 1E |
| UniProt Accession | P28566 |
| Component Type | Protein |
| Sequence Length | 365 aa |
5-hydroxytryptamine receptor 1E
Review this target as 5-hydroxytryptamine receptor 1E, mapped to UniProt P28566. Sequence length is 365 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL39 | 8.4 | Ki | 4.0 | Clinical |
| CHEMBL432713 | 8.2 | Ki | 6.31 | Preclinical |
| CHEMBL65547 | 7.36 | Ki | 44.0 | Clinical |
| CHEMBL263881 | 7.03 | Ki | 93.0 | Clinical |
| CHEMBL22744 | 7.0 | IC50 | 99.0 | Preclinical |
| CHEMBL3039520 | 6.9 | Ki | 126.87 | Approved |
| CHEMBL138989 | 6.85 | Ki | 140.0 | Preclinical |
| CHEMBL5091373 | 6.75 | Ki | 180.0 | Preclinical |
| CHEMBL137781 | 6.7 | Ki | 200.0 | Preclinical |
| CHEMBL343755 | 6.55 | Ki | 280.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 106 | 52 | 6.0 |
| cell-based format | 34 | 22 | 5.7 |
| assay format | 2 | 3 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 18 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |