Assay Detail
Binding
CHEMBL5442190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PDSP Secondary Binding target: OPRM1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | PDSP assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - PDSP Secondary Binding
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.41 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | 4.0 | 1 | 8.59 |
| CHEMBL1255661 | — | — | 1 | 8.03 |
| CHEMBL300555 | SPIROXATRINE | 2.0 | 1 | 7.89 |
| CHEMBL25230 | — | — | 1 | 7.83 |
| CHEMBL445102 | — | — | 1 | 7.29 |
| CHEMBL1474387 | — | — | 1 | 6.99 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 6.89 |
| CHEMBL5087624 | — | — | 1 | 6.85 |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | 4.0 | 1 | 6.81 |
| CHEMBL79834 | SPIRAMIDE | 2.0 | 1 | 6.81 |
| CHEMBL2138684 | FROVATRIPTAN SUCCINATE | 4.0 | 1 | 6.73 |
| CHEMBL1256844 | — | — | 1 | 6.73 |
| CHEMBL540612 | — | — | 1 | 6.60 |
| CHEMBL1256750 | — | — | 1 | 6.49 |
| CHEMBL513136 | — | — | 1 | 6.49 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 6.46 |
| CHEMBL344159 | TOLVAPTAN | 4.0 | 1 | 6.39 |
| CHEMBL531742 | — | — | 1 | 6.30 |
| CHEMBL1615374 | VILAZODONE HYDROCHLORIDE | 4.0 | 1 | 6.14 |
| CHEMBL59898 | — | — | 1 | 5.95 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | 4.0 | 1 | 5.89 |
| CHEMBL2391908 | — | — | 1 | 5.89 |
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | 4.0 | 1 | 5.75 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | 2.0 | 1 | 5.66 |
| CHEMBL1516474 | TEGASEROD MALEATE | 4.0 | 1 | 5.55 |
| CHEMBL259656 | — | — | 1 | 5.50 |
| CHEMBL542139 | — | — | 1 | 5.45 |
| CHEMBL1766103 | — | — | 1 | 5.25 |
| CHEMBL2440454 | — | — | 1 | 5.20 |
| CHEMBL1376064 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | Ki | = | 2.587 | nM | 8.59 |
| CHEMBL1255661 | — | Ki | = | 9.376 | nM | 8.03 |
| CHEMBL300555 | SPIROXATRINE | Ki | = | 12.81 | nM | 7.89 |
| CHEMBL25230 | — | Ki | = | 14.68 | nM | 7.83 |
| CHEMBL445102 | — | Ki | = | 51.53 | nM | 7.29 |
| CHEMBL1474387 | — | Ki | = | 102.35 | nM | 6.99 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 128.53 | nM | 6.89 |
| CHEMBL5087624 | — | Ki | = | 142.4 | nM | 6.85 |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | Ki | = | 154.01 | nM | 6.81 |
| CHEMBL79834 | SPIRAMIDE | Ki | = | 155.54 | nM | 6.81 |
| CHEMBL2138684 | FROVATRIPTAN SUCCINATE | Ki | = | 186.98 | nM | 6.73 |
| CHEMBL1256844 | — | Ki | = | 184.71 | nM | 6.73 |
| CHEMBL540612 | — | Ki | = | 249.03 | nM | 6.60 |
| CHEMBL1256750 | — | Ki | = | 323.0 | nM | 6.49 |
| CHEMBL513136 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL267777 | RITANSERIN | Ki | = | 344.27 | nM | 6.46 |
| CHEMBL344159 | TOLVAPTAN | Ki | = | 410.01 | nM | 6.39 |
| CHEMBL531742 | — | Ki | = | 494.94 | nM | 6.30 |
| CHEMBL1615374 | VILAZODONE HYDROCHLORIDE | Ki | = | 729.62 | nM | 6.14 |
| CHEMBL59898 | — | Ki | = | 1130.71 | nM | 5.95 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | Ki | = | 1295.69 | nM | 5.89 |
| CHEMBL2391908 | — | Ki | = | 1280.71 | nM | 5.89 |
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | Ki | = | 1791.02 | nM | 5.75 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | Ki | = | 2205.47 | nM | 5.66 |
| CHEMBL1516474 | TEGASEROD MALEATE | Ki | = | 2846.43 | nM | 5.55 |
| CHEMBL259656 | — | Ki | = | 3141.95 | nM | 5.50 |
| CHEMBL542139 | — | Ki | = | 3579.73 | nM | 5.45 |
| CHEMBL1766103 | — | Ki | = | 5565.45 | nM | 5.25 |
| CHEMBL2440454 | — | Ki | = | 6269.02 | nM | 5.20 |
| CHEMBL1376064 | — | Ki | = | 7852.36 | nM | 5.11 |
| CHEMBL3675743 | — | Ki | = | 7723.25 | nM | 5.11 |
| CHEMBL2392141 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL494502 | — | Ki | > | 10000.0 | nM | - |