Compound Detail
CHEMBL2107572
TECALCET HYDROCHLORIDE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2107572 |
| Name | TECALCET HYDROCHLORIDE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | YJXUXANREVNZLH-PFEQFJNWSA-N |
| Parent Compound | CHEMBL292376 |
| Active Moiety | CHEMBL292376 |
18
Targets
18
Activities
3
Assay Types
0
PK Parameters
20
Publications
9
Known Names
1
Mechanisms
Molecular Properties
303.8
MW (Da)
4.63
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.75
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Calcium sensing receptor modulator | MODULATOR | Extracellular calcium-sensing receptor | ✓ | ✓ |
Activity Summary
Ki 16 meas. best 7.38
EC50 1 meas. best 7.1
IC50 1 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.38 | 7.38 | 41.5 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | Ki | 7.37 | 7.37 | 43.0 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105907 | Ki | 7.13 | 7.13 | 74.6 | 1 |
| Extracellular calcium-sensing receptor CHEMBL1878 | EC50 | 7.1 | 7.1 | 80.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 6.79 | 6.79 | 162.3 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.74 | 6.74 | 181.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 6.06 | 6.06 | 874.6 | 1 |
| Histamine H1 receptor CHEMBL231 | Ki | 6.04 | 6.04 | 908.8 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 6.02 | 6.02 | 954.7 | 1 |
| 5-hydroxytryptamine receptor 5A CHEMBL3426 | Ki | 5.96 | 5.96 | 1091.1 | 1 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 5.85 | 5.85 | 1403.6 | 1 |
| Histamine H2 receptor CHEMBL1941 | Ki | 5.85 | 5.85 | 1401.8 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 5.84 | 5.84 | 1444.4 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 5.8 | 5.8 | 1581.2 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 5.71 | 5.71 | 1926.4 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 5.66 | 5.66 | 2205.5 | 1 |
| Psychosine receptor CHEMBL3714081 | IC50 | 5.66 | 5.66 | 2189.9 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 5.63 | 5.63 | 2316.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4689842 | HEK-293T | 345 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 345 |
| - | 10.6019/CHEMBL4689842 | U2OS | 344 |
| - | 10.6019/CHEMBL5209801 | Glucagon-like peptide 1 receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Glucose-dependent insulinotropic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Apelin receptor | 5 |
| - | 10.6019/CHEMBL5209801 | N-formyl peptide receptor 2 | 5 |
| - | 10.6019/CHEMBL5209801 | Free fatty acid receptor 4 | 5 |
| - | 10.6019/CHEMBL5209801 | Sphingosine 1-phosphate receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Adhesion G-protein coupled receptor F1 | 5 |
| - | 10.6019/CHEMBL5209801 | CX3C chemokine receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Type-1 angiotensin II receptor | 5 |
| - | 10.6019/CHEMBL5209801 | C5a anaphylatoxin chemotactic receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Alpha-2A adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Beta-2 adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | G-protein coupled receptor 35 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL5665443 | Uracil-DNA glycosylase | 1 |
| - | 10.6019/CHEMBL5060014 | Casein kinase I isoform delta | 1 |
| - | 10.6019/CHEMBL5060014 | Cyclin-dependent kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine