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Target Snapshot

CHEMBL3714081 Target Snapshot

Psychosine receptor · SINGLE PROTEIN · Homo sapiens

112Compounds
17Assays
7Approved Drugs
99.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q8IYL9. Use UniProt Q8IYL9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8IYL9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Psychosine receptor as ChEMBL target CHEMBL3714081, mapped to UniProt Q8IYL9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Psychosine receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3714081
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8IYL9
G-protein coupled receptor 65
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Psychosine receptor is the right protein anchor across sources, using UniProt Q8IYL9 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelG-protein coupled receptor 65
UniProt AccessionQ8IYL9
Component TypeProtein
Sequence Length337 aa

G-protein coupled receptor 65

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Psychosine receptor, mapped to UniProt Q8IYL9. ChEMBL maps the protein component as G-protein coupled receptor 65. Sequence length is 337 aa.

Mapped IDQ8IYL9
Review namePsychosine receptor
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
4
Phase II
Assay Mix

Activity Type Distribution

IC5096.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL449588 6.44 IC50 364.84 Preclinical
CHEMBL1492152 6.3 EC50 501.19 Preclinical
CHEMBL5406392 6.3 IC50 500.0 Preclinical
CHEMBL5398106 6.3 IC50 500.0 Preclinical
CHEMBL5400100 6.3 IC50 500.0 Preclinical
CHEMBL5400228 6.3 IC50 500.0 Preclinical
CHEMBL5402018 6.3 IC50 500.0 Preclinical
CHEMBL5403385 6.3 IC50 500.0 Preclinical
CHEMBL5404390 6.3 IC50 500.0 Preclinical
CHEMBL5406035 6.3 IC50 500.0 Preclinical
Distribution

pChEMBL Value Distribution

17
5.0
17
5.5
24
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

17
Total Assays
57
Tested Compounds
2
Assay Types
Functional — 14 assays, 57 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 57 5.8
Binding — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 0
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine