Assay Detail
Binding
CHEMBL5442205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PDSP Secondary Binding target: HTR2A - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | PDSP assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - PDSP Secondary Binding
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 6.48 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74355 | VOLINANSERIN | 3.0 | 1 | 9.10 |
| CHEMBL1215661 | PRUVANSERIN | 2.0 | 1 | 8.58 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 8.38 |
| CHEMBL83894 | FANANSERIN | 2.0 | 1 | 8.32 |
| CHEMBL1489369 | — | — | 1 | 7.92 |
| CHEMBL79834 | SPIRAMIDE | 2.0 | 1 | 7.82 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | 4.0 | 1 | 7.81 |
| CHEMBL543113 | — | — | 1 | 7.76 |
| CHEMBL2105760 | BREXPIPRAZOLE | 4.0 | 1 | 7.74 |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | 4.0 | 1 | 7.68 |
| CHEMBL5089005 | — | — | 1 | 7.45 |
| CHEMBL1633 | KETOTIFEN FUMARATE | 4.0 | 1 | 7.36 |
| CHEMBL2024517 | CARIPRAZINE HYDROCHLORIDE | 4.0 | 1 | 7.21 |
| CHEMBL4743049 | — | — | 1 | 6.98 |
| CHEMBL5075931 | — | — | 1 | 6.96 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | 2.0 | 1 | 6.74 |
| CHEMBL103769 | — | — | 1 | 6.69 |
| CHEMBL1200809 | AZELASTINE HYDROCHLORIDE | 4.0 | 1 | 6.64 |
| CHEMBL1516474 | TEGASEROD MALEATE | 4.0 | 1 | 6.37 |
| CHEMBL531742 | — | — | 1 | 6.26 |
| CHEMBL300555 | SPIROXATRINE | 2.0 | 1 | 6.15 |
| CHEMBL589390 | LATREPIRDINE | 3.0 | 1 | 6.14 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | 4.0 | 1 | 6.08 |
| CHEMBL445102 | — | — | 1 | 6.05 |
| CHEMBL1256998 | — | — | 1 | 6.02 |
| CHEMBL3716980 | — | — | 1 | 6.01 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 5.89 |
| CHEMBL567303 | PALOSURAN | 2.0 | 1 | 5.80 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | 4.0 | 1 | 5.75 |
| CHEMBL281350 | SB-224289 | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74355 | VOLINANSERIN | Ki | = | 0.7877 | nM | 9.10 |
| CHEMBL1215661 | PRUVANSERIN | Ki | = | 2.638 | nM | 8.58 |
| CHEMBL267777 | RITANSERIN | Ki | = | 4.221 | nM | 8.38 |
| CHEMBL83894 | FANANSERIN | Ki | = | 4.784 | nM | 8.32 |
| CHEMBL1489369 | — | Ki | = | 11.89 | nM | 7.92 |
| CHEMBL79834 | SPIRAMIDE | Ki | = | 15.05 | nM | 7.82 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | Ki | = | 15.62 | nM | 7.81 |
| CHEMBL543113 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL2105760 | BREXPIPRAZOLE | Ki | = | 18.26 | nM | 7.74 |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | Ki | = | 21.05 | nM | 7.68 |
| CHEMBL5089005 | — | Ki | = | 35.74 | nM | 7.45 |
| CHEMBL1633 | KETOTIFEN FUMARATE | Ki | = | 43.93 | nM | 7.36 |
| CHEMBL2024517 | CARIPRAZINE HYDROCHLORIDE | Ki | = | 61.19 | nM | 7.21 |
| CHEMBL4743049 | — | Ki | = | 104.86 | nM | 6.98 |
| CHEMBL5075931 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | Ki | = | 180.96 | nM | 6.74 |
| CHEMBL103769 | — | Ki | = | 202.3 | nM | 6.69 |
| CHEMBL1200809 | AZELASTINE HYDROCHLORIDE | Ki | = | 229.61 | nM | 6.64 |
| CHEMBL1516474 | TEGASEROD MALEATE | Ki | = | 431.42 | nM | 6.37 |
| CHEMBL531742 | — | Ki | = | 548.24 | nM | 6.26 |
| CHEMBL300555 | SPIROXATRINE | Ki | = | 702.1 | nM | 6.15 |
| CHEMBL589390 | LATREPIRDINE | Ki | = | 725.83 | nM | 6.14 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | Ki | = | 841.68 | nM | 6.08 |
| CHEMBL445102 | — | Ki | = | 898.67 | nM | 6.05 |
| CHEMBL1256998 | — | Ki | = | 963.6 | nM | 6.02 |
| CHEMBL3716980 | — | Ki | = | 982.99 | nM | 6.01 |
| CHEMBL1263 | SALMETEROL | Ki | = | 1274.77 | nM | 5.89 |
| CHEMBL567303 | PALOSURAN | Ki | = | 1588.55 | nM | 5.80 |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | Ki | = | 1790.2 | nM | 5.75 |
| CHEMBL281350 | SB-224289 | Ki | = | 1784.23 | nM | 5.75 |
| CHEMBL1095777 | INDACATEROL | Ki | = | 2019.53 | nM | 5.70 |
| CHEMBL3342358 | — | Ki | = | 2119.58 | nM | 5.67 |
| CHEMBL9387 | L-365260 | Ki | = | 2140.92 | nM | 5.67 |
| CHEMBL3215877 | — | Ki | = | 2290.34 | nM | 5.64 |
| CHEMBL259656 | — | Ki | = | 2657.36 | nM | 5.58 |
| CHEMBL1474387 | — | Ki | = | 2787.73 | nM | 5.55 |
| CHEMBL1766103 | — | Ki | = | 3429.25 | nM | 5.46 |
| CHEMBL494502 | — | Ki | = | 3878.82 | nM | 5.41 |
| CHEMBL3338866 | MK-1064 | Ki | = | 4592.51 | nM | 5.34 |
| CHEMBL3741589 | — | Ki | = | 4606.27 | nM | 5.34 |
| CHEMBL519240 | — | Ki | = | 6425.4 | nM | 5.19 |
| CHEMBL260563 | — | Ki | = | 7872.27 | nM | 5.10 |
| CHEMBL1705 | CLONIDINE HYDROCHLORIDE | Ki | = | 9141.13 | nM | 5.04 |
| CHEMBL1593850 | — | Ki | = | 9751.39 | nM | 5.01 |
| CHEMBL502882 | — | Ki | > | 10000.0 | nM | - |