Compound Detail
CHEMBL9387
L-365260 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL9387 |
| Name | L-365260 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KDFQABSFVYLGPM-QFIPXVFZSA-N |
14
Targets
87
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
398.5
MW (Da)
3.96
ALogP
3
HBA
2
HBD
73.8
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 65 meas. best 8.96
Ki 21 meas. best 9.83
Kd 1 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholecystokinin receptor type A CHEMBL2871 | Ki | 9.83 | 9.83 | 0.1 | 1 |
| Gastrin/cholecystokinin type B receptor CHEMBL298 | IC50 | 8.96 | 8.3592 | 1.1 | 26 |
| Gastrin/cholecystokinin type B receptor CHEMBL298 | Ki | 8.8 | 8.3925 | 1.6 | 8 |
| Cholecystokinin receptor type A CHEMBL3501 | IC50 | 8.7 | 7.4775 | 2.0 | 4 |
| Gastrin/cholecystokinin type B receptor CHEMBL2854 | IC50 | 8.7 | 8.1033 | 2.0 | 9 |
| Gastrin/cholecystokinin type B receptor CHEMBL2854 | Ki | 8.43 | 8.415 | 3.7 | 2 |
| Gastrin/cholecystokinin type B receptor CHEMBL3508 | Ki | 7.92 | 7.5325 | 12.0 | 4 |
| Gastrin/cholecystokinin type B receptor CHEMBL3508 | Kd | 7.54 | 7.54 | 28.8 | 1 |
| Gastrin/cholecystokinin type B receptor CHEMBL3508 | IC50 | 7.41 | 7.41 | 39.0 | 2 |
| Cholecystokinin receptor type A CHEMBL1901 | IC50 | 6.8 | 6.8 | 158.5 | 1 |
| Cholecystokinin receptor type A CHEMBL1901 | Ki | 6.76 | 6.76 | 173.8 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.67 | 6.67 | 214.0 | 1 |
| Cholecystokinin receptor type A CHEMBL2871 | IC50 | 6.64 | 6.3831 | 230.0 | 16 |
| Cholecystokinin receptor type A CHEMBL3501 | Ki | 6.5 | 6.415 | 316.2 | 2 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 6.27 | 6.27 | 541.0 | 1 |
| AGS CHEMBL613860 | IC50 | 6.17 | 6.17 | 675.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 5.67 | 5.67 | 2140.9 | 1 |
| D(1A) dopamine receptor CHEMBL2056 | Ki | 5.52 | 5.52 | 3019.9 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.3 | 5.3 | 5000.0 | 2 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | Ki | 5.21 | 5.21 | 6207.3 | 1 |
| Cholecystokinin receptor type A CHEMBL2798 | IC50 | 4.96 | 4.96 | 11100.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4689842 | HEK-293T | 10 |
| - | 10.6019/CHEMBL4689842 | U2OS | 10 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 7 |
| - | 10.6019/CHEMBL5209801 | Glucose-dependent insulinotropic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | C5a anaphylatoxin chemotactic receptor 1 | 5 |
| - | 10.6019/CHEMBL5209801 | Beta-2 adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | N-formyl peptide receptor 2 | 5 |
| - | 10.6019/CHEMBL5209801 | CX3C chemokine receptor 1 | 5 |
| 2016728 | 10.1021/jm00108a040 | Gastrin/cholecystokinin type B receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Alpha-2A adrenergic receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Free fatty acid receptor 4 | 5 |
| - | 10.6019/CHEMBL5209801 | Glucagon-like peptide 1 receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Type-1 angiotensin II receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Apelin receptor | 5 |
| - | 10.6019/CHEMBL5209801 | Adhesion G-protein coupled receptor F1 | 5 |
| - | 10.6019/CHEMBL5209801 | Sphingosine 1-phosphate receptor 1 | 5 |
| 19113864 | 10.1021/jm800174p | Gastrin/cholecystokinin type B receptor | 4 |
| - | 10.1016/0960-894X(95)00556-9 | Rattus norvegicus | 3 |
| 11020274 | 10.1021/jm990967h | Gastrin/cholecystokinin type B receptor | 3 |
| - | 10.1039/C6MD00052E | NON-PROTEIN TARGET | 3 |
Data from ChEMBL 36 via Core Engine