Assay Detail
Binding
CHEMBL660356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
A new class of non-peptidic cholecystokinin-B/gastrin receptor antagonists based on dibenzobicyclo[2.2.2]octane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.14 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9387 | L-365260 | — | 1 | 8.43 |
| CHEMBL333920 | — | — | 3 | 7.39 |
| CHEMBL123344 | — | — | 1 | 6.72 |
| CHEMBL332510 | — | — | 1 | 6.67 |
| CHEMBL332873 | — | — | 1 | 6.27 |
| CHEMBL332782 | — | — | 1 | 6.05 |
| CHEMBL331177 | — | — | 1 | 5.81 |
| CHEMBL333758 | — | — | 1 | 5.72 |
| CHEMBL331324 | — | — | 1 | 5.60 |
| CHEMBL333664 | — | — | 1 | 5.33 |
| CHEMBL333409 | — | — | 1 | 5.12 |
| CHEMBL332061 | — | — | 1 | 5.05 |
| CHEMBL121342 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9387 | L-365260 | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL333920 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL333920 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL123344 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL332510 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL332873 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL333920 | — | Ki | = | 776.25 | nM | 6.11 |
| CHEMBL332782 | — | Ki | = | 891.25 | nM | 6.05 |
| CHEMBL331177 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL333758 | — | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL331324 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL333664 | — | Ki | = | 4677.35 | nM | 5.33 |
| CHEMBL333409 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL332061 | — | Ki | = | 8912.51 | nM | 5.05 |
| CHEMBL121342 | — | Ki | = | 10000.0 | nM | 5.00 |