Assay Detail
Binding
CHEMBL662290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.26 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138534 | — | — | 1 | 9.82 |
| CHEMBL9387 | L-365260 | — | 1 | 8.70 |
| CHEMBL333081 | — | — | 1 | 7.72 |
| CHEMBL70380 | — | — | 1 | 6.82 |
| CHEMBL420320 | — | — | 1 | 6.59 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.57 |
| CHEMBL117281 | — | — | 1 | 6.43 |
| CHEMBL419764 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138534 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL9387 | L-365260 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL333081 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL70380 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL420320 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL117281 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL419764 | — | IC50 | = | 3700.0 | nM | 5.43 |