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Assay Detail

CHEMBL663090

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Gastrin/cholecystokinin type B receptor (CHEMBL298)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
Bellier B, McCort-Tranchepain I, Ducos B, Danascimento S, Meudal H, Noble F, Garbay C, Roques BP.
J Med Chem (1997) 40 : 3947 -3956
PubMed 9397175 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 7.35 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2062154 CI-988 1.0 1 9.40
CHEMBL9387 L-365260 1 8.70
CHEMBL338526 1 8.21
CHEMBL338072 1 7.85
CHEMBL338300 1 7.75
CHEMBL338382 1 7.70
CHEMBL340327 1 7.62
CHEMBL406359 1 7.58
CHEMBL337934 1 7.58
CHEMBL341045 1 7.55
CHEMBL129070 1 7.50
CHEMBL337933 1 7.35
CHEMBL338525 1 7.34
CHEMBL434631 1 7.25
CHEMBL336965 1 7.20
CHEMBL339451 1 7.04
CHEMBL262679 1 7.01
CHEMBL338252 1 6.91
CHEMBL339931 1 6.54
CHEMBL339907 1 6.48
CHEMBL436382 1 6.21
CHEMBL126957 1 6.11
CHEMBL338752 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2062154 CI-988 Ki = 0.4 nM 9.40
CHEMBL9387 L-365260 Ki = 2.0 nM 8.70
CHEMBL338526 Ki = 6.1 nM 8.21
CHEMBL338072 Ki = 14.0 nM 7.85
CHEMBL338300 Ki = 17.6 nM 7.75
CHEMBL338382 Ki = 20.0 nM 7.70
CHEMBL340327 Ki = 24.0 nM 7.62
CHEMBL406359 Ki = 26.3 nM 7.58
CHEMBL337934 Ki = 26.2 nM 7.58
CHEMBL341045 Ki = 28.0 nM 7.55
CHEMBL129070 Ki = 32.0 nM 7.50
CHEMBL337933 Ki = 44.8 nM 7.35
CHEMBL338525 Ki = 45.7 nM 7.34
CHEMBL434631 Ki = 56.0 nM 7.25
CHEMBL336965 Ki = 63.0 nM 7.20
CHEMBL339451 Ki = 91.0 nM 7.04
CHEMBL262679 Ki = 98.0 nM 7.01
CHEMBL338252 Ki = 122.0 nM 6.91
CHEMBL339931 Ki = 285.0 nM 6.54
CHEMBL339907 Ki = 330.0 nM 6.48
CHEMBL436382 Ki = 620.0 nM 6.21
CHEMBL126957 Ki = 775.0 nM 6.11
CHEMBL338752 Ki = 791.0 nM 6.10