Assay Detail
Binding
CHEMBL663092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of a potent and selective non-peptide CCK-B/gastrin receptor antagonist tritiated ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.36 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.19 |
| CHEMBL2062154 | CI-988 | 1.0 | 1 | 9.01 |
| CHEMBL9387 | L-365260 | — | 1 | 8.74 |
| CHEMBL1328 | PENTAGASTRIN | 4.0 | 1 | 7.66 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL2062154 | CI-988 | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL9387 | L-365260 | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1328 | PENTAGASTRIN | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL9506 | DEVAZEPIDE | Ki | = | 62.0 | nM | 7.21 |