Assay Detail
Binding
CHEMBL656251
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Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.34 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445095 | — | — | 1 | 9.55 |
| CHEMBL38404 | — | — | 1 | 9.00 |
| CHEMBL417521 | — | — | 1 | 8.92 |
| CHEMBL9387 | L-365260 | — | 1 | 8.70 |
| CHEMBL169661 | — | — | 1 | 8.26 |
| CHEMBL289498 | — | — | 1 | 8.15 |
| CHEMBL41361 | — | — | 1 | 7.64 |
| CHEMBL70380 | — | — | 1 | 6.82 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.61 |
| CHEMBL289533 | — | — | 1 | 6.52 |
| CHEMBL355092 | — | — | 1 | 6.39 |
| CHEMBL40668 | — | — | 1 | 5.72 |
| CHEMBL1907852 | — | — | 1 | 5.54 |
| CHEMBL2092868 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445095 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL38404 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL417521 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL9387 | L-365260 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL169661 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL289498 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL41361 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL70380 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL289533 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL355092 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL40668 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1907852 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2092868 | — | IC50 | = | 11000.0 | nM | 4.96 |