Assay Detail
Binding
CHEMBL657476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diphenylpyrazolidinone and benzodiazepine cholecystokinin antagonists: A case of convergent evolution in medicinal chemistry
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.34 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9387 | L-365260 | — | 1 | 8.70 |
| CHEMBL70380 | — | — | 1 | 6.82 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.57 |
| CHEMBL168852 | — | — | 1 | 5.54 |
| CHEMBL419764 | — | — | 1 | 5.43 |
| CHEMBL169438 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9387 | L-365260 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL70380 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL168852 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL419764 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL169438 | — | IC50 | = | 11000.0 | nM | 4.96 |