Assay Detail
Binding
CHEMBL657374
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Inhibition by displacing [3H]CCK-8S against Cholecystokinin type A receptor of rat pancreatic membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.83 | 9.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 9.83 |
| CHEMBL2062154 | CI-988 | 1.0 | 1 | 9.83 |
| CHEMBL9387 | L-365260 | — | 1 | 9.83 |
| CHEMBL330977 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | Ki | = | 0.1479 | nM | 9.83 |
| CHEMBL2062154 | CI-988 | Ki | = | 0.1479 | nM | 9.83 |
| CHEMBL9387 | L-365260 | Ki | = | 0.1479 | nM | 9.83 |
| CHEMBL330977 | — | Ki | = | 1479.11 | nM | 5.83 |