5-hydroxytryptamine receptor 5A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P47898. Use UniProt P47898 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P47898 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 5A
Review this target as 5-hydroxytryptamine receptor 5A, mapped to UniProt P47898. Sequence length is 357 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 5A as ChEMBL target CHEMBL3426, mapped to UniProt P47898. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-hydroxytryptamine receptor 5A is the right protein anchor across sources, using UniProt P47898 as the stable mapping.
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| Preferred Name | 5-hydroxytryptamine receptor 5A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P47898 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 5A |
| UniProt Accession | P47898 |
| Component Type | Protein |
| Sequence Length | 357 aa |
5-hydroxytryptamine receptor 5A
Review this target as 5-hydroxytryptamine receptor 5A, mapped to UniProt P47898. Sequence length is 357 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3654198 | 9.17 | Ki | 0.68 | Preclinical |
| CHEMBL3654206 | 9.12 | Ki | 0.75 | Preclinical |
| CHEMBL282199 | 9.11 | Ki | 0.78 | Preclinical |
| CHEMBL3654212 | 9.07 | Ki | 0.85 | Preclinical |
| CHEMBL3654208 | 9.06 | Ki | 0.88 | Preclinical |
| CHEMBL3654214 | 9.02 | Ki | 0.95 | Preclinical |
| CHEMBL1210154 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL93240 | 9.0 | Ki | 1.0 | Clinical |
| CHEMBL3654199 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL3654197 | 8.96 | Ki | 1.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 215 | 210 | 6.5 |
| cell-based format | 55 | 145 | 7.0 |
| assay format | 2 | 16 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 8 | 5.6 |
| assay format | 5 | 2 | 8.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
| single protein format | 1 | 0 | — |