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Evidence Snapshot

5-hydroxytryptamine receptor 5A

CHEMBL3426 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3426
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 5-hydroxytryptamine receptor 5A as ChEMBL target CHEMBL3426, mapped to UniProt P47898. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
5-hydroxytryptamine receptor 5A
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3426
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P47898
5-hydroxytryptamine receptor 5A
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why 5-hydroxytryptamine receptor 5A matters

As of 2026-09-13

5-hydroxytryptamine receptor 5A is reviewed as 5-hydroxytryptamine receptor 5A (UniProt P47898); the current evidence base includes 14 approved drugs, 1475 compounds, and 287 assays, with lead potency reaching pChEMBL 9.2.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 14 approved drugs, 1475 compounds, and 287 assays for this target. The dominant activity type is KI. CHEMBL3654198 is the current potency anchor at pChEMBL 9.2.

Use CHEMBL3654198 as the tractability anchor when discussing potency (pChEMBL 9.2).

Activity source · ChEMBL 36 via Core Engine
14 approved pChEMBL 9.2
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why 5-hydroxytryptamine receptor 5A matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P47898, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1475
Total Compounds
287
Total Assays
14
Approved Drugs
IC50: 57.0, KI: 601.0, EC50: 231.0, KD: 4.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3654198
 9.2 Ki —
No preferred name
CHEMBL3654206
 9.1 Ki —
No preferred name
CHEMBL282199
 9.1 Ki —
No preferred name
CHEMBL3654212
 9.1 Ki —
No preferred name
CHEMBL3654208
 9.1 Ki —

Approved Drugs

Structure Compound First Approval
BREXPIPRAZOLE
CHEMBL2105760
 2015
CINACALCET HYDROCHLORIDE
CHEMBL1200776
 2004
TEGASEROD MALEATE
CHEMBL1516474
 2002
ARIPIPRAZOLE
CHEMBL1112
 2002
RISPERIDONE
CHEMBL85
 1993
SUMATRIPTAN
CHEMBL128
 1992
CLOZAPINE
CHEMBL42
 1989
PRAZOSIN HYDROCHLORIDE
CHEMBL1558
 1976
ERGOTAMINE
CHEMBL442
 1948
DIHYDROERGOTAMINE MESYLATE
CHEMBL1200517
 1946
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:43Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3426