Assay Detail
Binding
CHEMBL5442187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PDSP Secondary Binding target: OPRK1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | PDSP assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - PDSP Secondary Binding
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.57 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4750757 | — | — | 1 | 9.23 |
| CHEMBL1256750 | — | — | 1 | 8.75 |
| CHEMBL1255661 | — | — | 1 | 8.67 |
| CHEMBL5076917 | — | — | 1 | 8.39 |
| CHEMBL25230 | — | — | 1 | 7.63 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | 4.0 | 1 | 7.14 |
| CHEMBL513136 | — | — | 1 | 7.12 |
| CHEMBL74355 | VOLINANSERIN | 3.0 | 1 | 6.99 |
| CHEMBL1474387 | — | — | 1 | 6.93 |
| CHEMBL2018875 | — | — | 1 | 6.71 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 6.46 |
| CHEMBL3039520 | LASMIDITAN | 4.0 | 1 | 6.45 |
| CHEMBL4202825 | — | — | 1 | 6.39 |
| CHEMBL1256844 | — | — | 1 | 6.35 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | 4.0 | 1 | 6.35 |
| CHEMBL256470 | — | — | 1 | 6.31 |
| CHEMBL259656 | — | — | 1 | 6.30 |
| CHEMBL2110363 | — | — | 1 | 6.15 |
| CHEMBL300555 | SPIROXATRINE | 2.0 | 1 | 6.15 |
| CHEMBL542139 | — | — | 1 | 6.05 |
| CHEMBL79834 | SPIRAMIDE | 2.0 | 1 | 6.04 |
| CHEMBL3342358 | — | — | 1 | 6.00 |
| CHEMBL2391908 | — | — | 1 | 5.96 |
| CHEMBL2181226 | — | — | 1 | 5.95 |
| CHEMBL103769 | — | — | 1 | 5.95 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | 2.0 | 1 | 5.85 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 5.84 |
| CHEMBL59898 | — | — | 1 | 5.71 |
| CHEMBL360648 | — | — | 1 | 5.69 |
| CHEMBL1600943 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4750757 | — | Ki | = | 0.5913 | nM | 9.23 |
| CHEMBL1256750 | — | Ki | = | 1.792 | nM | 8.75 |
| CHEMBL1255661 | — | Ki | = | 2.143 | nM | 8.67 |
| CHEMBL5076917 | — | Ki | = | 4.034 | nM | 8.39 |
| CHEMBL25230 | — | Ki | = | 23.34 | nM | 7.63 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | Ki | = | 71.57 | nM | 7.14 |
| CHEMBL513136 | — | Ki | = | 76.12 | nM | 7.12 |
| CHEMBL74355 | VOLINANSERIN | Ki | = | 102.71 | nM | 6.99 |
| CHEMBL1474387 | — | Ki | = | 118.1 | nM | 6.93 |
| CHEMBL2018875 | — | Ki | = | 194.98 | nM | 6.71 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 346.85 | nM | 6.46 |
| CHEMBL3039520 | LASMIDITAN | Ki | = | 356.57 | nM | 6.45 |
| CHEMBL4202825 | — | Ki | = | 406.53 | nM | 6.39 |
| CHEMBL1256844 | — | Ki | = | 447.61 | nM | 6.35 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | Ki | = | 444.22 | nM | 6.35 |
| CHEMBL256470 | — | Ki | = | 493.97 | nM | 6.31 |
| CHEMBL259656 | — | Ki | = | 502.75 | nM | 6.30 |
| CHEMBL2110363 | — | Ki | = | 703.8 | nM | 6.15 |
| CHEMBL300555 | SPIROXATRINE | Ki | = | 711.3 | nM | 6.15 |
| CHEMBL542139 | — | Ki | = | 898.05 | nM | 6.05 |
| CHEMBL79834 | SPIRAMIDE | Ki | = | 913.9 | nM | 6.04 |
| CHEMBL3342358 | — | Ki | = | 997.55 | nM | 6.00 |
| CHEMBL2391908 | — | Ki | = | 1110.2 | nM | 5.96 |
| CHEMBL2181226 | — | Ki | = | 1133.31 | nM | 5.95 |
| CHEMBL103769 | — | Ki | = | 1113.27 | nM | 5.95 |
| CHEMBL2107572 | TECALCET HYDROCHLORIDE | Ki | = | 1403.62 | nM | 5.85 |
| CHEMBL267777 | RITANSERIN | Ki | = | 1445.44 | nM | 5.84 |
| CHEMBL59898 | — | Ki | = | 1941.19 | nM | 5.71 |
| CHEMBL360648 | — | Ki | = | 2048.33 | nM | 5.69 |
| CHEMBL1600943 | — | Ki | = | 2122.51 | nM | 5.67 |
| CHEMBL502182 | ELAGOLIX SODIUM | Ki | = | 2383.41 | nM | 5.62 |
| CHEMBL83894 | FANANSERIN | Ki | = | 2874.09 | nM | 5.54 |