Sigma intracellular receptor 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q5BJF2. Use UniProt Q5BJF2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5BJF2 as the stable identity anchor, then attach disease evidence before program review.
Sigma intracellular receptor 2
Review this target as Sigma intracellular receptor 2, mapped to UniProt Q5BJF2. Sequence length is 176 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sigma intracellular receptor 2 as ChEMBL target CHEMBL4105907, mapped to UniProt Q5BJF2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sigma intracellular receptor 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q5BJF2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sigma intracellular receptor 2 |
| UniProt Accession | Q5BJF2 |
| Component Type | Protein |
| Sequence Length | 176 aa |
Sigma intracellular receptor 2
Review this target as Sigma intracellular receptor 2, mapped to UniProt Q5BJF2. Sequence length is 176 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL61479 | 9.92 | Ki | 0.12 | Clinical |
| CHEMBL227126 | 9.59 | Ki | 0.26 | Preclinical |
| CHEMBL53325 | 9.47 | Ki | 0.34 | Preclinical |
| CHEMBL5426155 | 9.37 | Ki | 0.43 | Preclinical |
| CHEMBL4853196 | 9.36 | Ki | 0.44 | Preclinical |
| CHEMBL5928382 | 9.28 | Ki | 0.53 | Preclinical |
| CHEMBL5278003 | 9.24 | Ki | 0.58 | Preclinical |
| CHEMBL4647871 | 9.23 | Ki | 0.59 | Preclinical |
| CHEMBL5979974 | 9.17 | Ki | 0.67 | Preclinical |
| CHEMBL5395523 | 9.0 | Ki | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 147 | 463 | 6.6 |
| cell-based format | 23 | 196 | 7.2 |
| cell membrane format | 9 | 68 | 6.9 |
| assay format | 4 | 112 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 1 | 5.6 |