Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1237055

HYDROMORPHONE HYDROCHLORIDE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5.Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1237055
Name HYDROMORPHONE HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key XHILEZUETWRSHC-NRGUFEMZSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL398707
Active Moiety CHEMBL398707

Known Names

Dilaudid Dilaudid-hp Exalgo Hydromorphone hcl Hydromorphone hydrochloride Hydromorphone hydrochloride cii NSC-117862 Palladone Palladone-sr
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
9
Known Names
9
Indications
1
Mechanisms

Molecular Properties

285.3
MW (Da)
1.63
ALogP
4
HBA
1
HBD
49.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1984
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral Parenteral

Flags

Black Box Warning

Extended Properties

Molecular Formula C17H20ClNO3
MW 321.80
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness 2.07

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Mu opioid receptor agonist AGONIST Mu-type opioid receptor ✓ ✓

Indications

Acute Pain Pain Substance-Related Disorders Back Pain Cancer Pain Chronic Pain Liver Diseases Osteoarthritis, Hip Osteoarthritis, Knee

Drug Warnings

Black Box Warning
misuse
Country: United States
Black Box Warning
respiratory toxicity
Country: United States

Activity Summary

EC50 1 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Opioid receptor
CHEMBL2094129
 EC50 9.0 9.0 1.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Opioid receptor EC50 = 1.0 nM 9.0 Binding affinity to opioid receptor in rat brain homogenates 218012

Literature References

PubMed DOI Target Context # Activities
25147603 10.1021/ml500117c Mus musculus 6
218012 10.1021/jm00189a007 Mus musculus 2
6716400 10.1021/jm00371a013 Mus musculus 1
218012 10.1021/jm00189a007 Opioid receptor 1

Data from ChEMBL 36 via Core Engine