Assay Detail
Binding
CHEMBL3230951
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Binding affinity to opioid receptor in rat brain homogenates
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.00 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3228684 | — | — | 1 | 9.22 |
| CHEMBL1237055 | HYDROMORPHONE HYDROCHLORIDE | 4.0 | 1 | 9.00 |
| CHEMBL1908349 | NALORPHINE HYDROCHLORIDE | -1.0 | 1 | 8.82 |
| CHEMBL2096625 | — | — | 1 | 8.52 |
| CHEMBL543073 | — | — | 1 | 8.52 |
| CHEMBL3228683 | — | — | 1 | 8.00 |
| CHEMBL3228681 | — | — | 1 | 7.70 |
| CHEMBL3228679 | — | — | 1 | 7.22 |
| CHEMBL3228680 | — | — | 1 | 7.05 |
| CHEMBL85457 | — | — | 1 | 7.00 |
| CHEMBL3228682 | — | — | 1 | 7.00 |
| CHEMBL2062261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3228684 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1237055 | HYDROMORPHONE HYDROCHLORIDE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1908349 | NALORPHINE HYDROCHLORIDE | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2096625 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL543073 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3228683 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3228681 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3228679 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3228680 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL85457 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3228682 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2062261 | — | EC50 | = | 0.7 | nM | - |