Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1200794

OXYMORPHONE HYDROCHLORIDE
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5.Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1200794
Name OXYMORPHONE HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key BCGJBQBWUGVESK-KCTCKCTRSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL963
Active Moiety CHEMBL963

Known Names

Numorphan Opana Opana er Oxymorphone hcl Oxymorphone hydrochloride
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
5
Known Names
4
Indications
1
Mechanisms

Molecular Properties

301.3
MW (Da)
0.75
ALogP
5
HBA
2
HBD
70.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1959
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral Parenteral Topical

Flags

Black Box Warning

Extended Properties

Molecular Formula C17H20ClNO4
MW 337.80
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness 2.20

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Opioid receptors; mu/kappa/delta agonist AGONIST Opioid receptors; mu/kappa/delta ✓ ✓

Indications

Acute Pain Pain Pain, Postoperative Chronic Pain

Drug Warnings

Black Box Warning
respiratory toxicity
Country: United States
Black Box Warning
misuse
Country: United States

Activity Summary

EC50 1 meas. best 6.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Opioid receptor
CHEMBL2094129
 EC50 6.6 6.6 250.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Opioid receptor EC50 = 250.0 nM 6.6 Binding affinity to opiate receptor in rat brain homogenates 218015

Literature References

PubMed DOI Target Context # Activities
218015 10.1021/jm00189a024 Rhesus monkey 2
218015 10.1021/jm00189a024 Mus musculus 1
218015 10.1021/jm00189a024 Opioid receptor 1

Data from ChEMBL 36 via Core Engine