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Compound Detail

CHEMBL6067642

CODEINE PHOSPHATE
💊 Approved Drug
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💊 Approved Drug
COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341.COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341.O.O=P(O)(O)O.O=P(O)(O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL6067642
Name CODEINE PHOSPHATE
Phase Approved
Structure Type MOL
InChI Key DKSZLDSPXIWGFO-BLOJGBSASA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL485
Active Moiety CHEMBL485

Known Names

Ambenyl cough syrup Bepro Codeine phosphate Codeine phosphate anhydrous Codeine phosphate bp Codeine phosphate cii Codeine phosphate component of ambenyl Codeine phosphate component of bromanate dc Codeine phosphate component of bromanyl Codeine phosphate component of codrix Codeine phosphate component of dimetane-dc Codeine phosphate component of myphetane dc +7 more
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
20
Publications
19
Known Names
7
Indications
1
Mechanisms

Molecular Properties

299.4
MW (Da)
1.50
ALogP
4
HBA
1
HBD
41.9
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1952
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral

Extended Properties

Molecular Formula C36H50N2O15P2
MW 812.74
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness 2.27

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Opioid receptors; mu/kappa/delta agonist AGONIST Opioid receptors; mu/kappa/delta ✓ ✓

Indications

Migraine Disorders Pain Spasm Substance-Related Disorders HIV Infections Sciatica Cough

Activity Summary

EC50 1 meas.
IC50 1 meas. best 8.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Opioid receptor
CHEMBL2094129
 IC50 8.0 8.0 10.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Opioid receptor IC50 = 10.0 nM 8.0 50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiat... 2863378

Literature References

PubMed DOI Target Context # Activities
106119 10.1021/jm00187a014 Mus musculus 7
2876100 10.1021/jm00160a022 Mus musculus 4
6088771 10.1021/jm00375a024 Mus musculus 4
2863378 10.1021/jm00147a009 Mus musculus 4
722742 10.1021/jm00210a031 Mus musculus 3
401892 10.1021/jm00212a007 Mus musculus 3
106119 10.1021/jm00187a014 Rattus norvegicus 3
7265131 10.1021/jm00136a016 Mus musculus 2
7241504 10.1021/jm00137a002 Rattus norvegicus 2
7853344 10.1021/jm00003a014 Cavia porcellus 2
218015 10.1021/jm00189a024 Mus musculus 2
218015 10.1021/jm00189a024 Rhesus monkey 2
1495016 10.1021/jm00093a019 Mus musculus 2
7154008 10.1021/jm00354a016 Mus musculus 1
6088771 10.1021/jm00375a024 Opioid receptor 1
2863378 10.1021/jm00147a009 Opioid receptor 1
7241504 10.1021/jm00137a002 Mus musculus 1
24249037 10.1007/s11095-013-1232-z No relevant target 1
6481763 10.1021/jm00376a008 Rattus norvegicus 1
7674 10.1021/jm00228a013 Mus musculus 1

Data from ChEMBL 36 via Core Engine