Assay Detail
Binding
CHEMBL749840
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50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Acylmorphinans. A novel class of potent analgesic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.92 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067642 | CODEINE PHOSPHATE | 4.0 | 1 | 8.00 |
| CHEMBL1202420 | — | — | 1 | 7.85 |
| CHEMBL1202422 | — | — | 1 | 7.16 |
| CHEMBL17884 | — | — | 1 | 6.68 |
| CHEMBL17681 | — | — | 1 | 4.89 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | - |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067642 | CODEINE PHOSPHATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1202420 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1202422 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL17884 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL17681 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL70 | MORPHINE | IC50 | = | 0.027 | nM | - |
| CHEMBL592 | LEVORPHANOL | IC50 | = | 0.004 | nM | - |