Assay Detail
Binding
CHEMBL753910
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Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.70 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149414 | — | — | 1 | 9.52 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 9.00 |
| CHEMBL340032 | DADLE | — | 1 | 6.20 |
| CHEMBL1500 | DIHYDROMORPHINE | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149414 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL80 | NALOXONE | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL340032 | DADLE | Kd | = | 625.0 | nM | 6.20 |
| CHEMBL1500 | DIHYDROMORPHINE | Kd | = | 830.0 | nM | 6.08 |