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Target Snapshot

CHEMBL3614 Target Snapshot

Kappa-type opioid receptor · SINGLE PROTEIN · Rattus norvegicus

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535Compounds
173Assays
6Approved Drugs
528.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P34975. Use UniProt P34975 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P34975 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Kappa-type opioid receptor as ChEMBL target CHEMBL3614, mapped to UniProt P34975. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Kappa-type opioid receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3614
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P34975
Kappa-type opioid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Kappa-type opioid receptor is the right protein anchor across sources, using UniProt P34975 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKappa-type opioid receptor
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP34975
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKappa-type opioid receptor
UniProt AccessionP34975
Component TypeProtein
Sequence Length380 aa

Kappa-type opioid receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Kappa-type opioid receptor, mapped to UniProt P34975. Sequence length is 380 aa.

Mapped IDP34975
Review nameKappa-type opioid receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

6
Approved
4
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5054.0
KI421.0
EC5035.0
KD18.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL281786 10.54 Kd 0.029 Clinical
CHEMBL485832 10.52 Ki 0.03 Preclinical
CHEMBL573214 10.15 Ki 0.07 Preclinical
CHEMBL318859 10.0 Ki 0.1 Clinical
CHEMBL405057 9.96 Ki 0.11 Preclinical
CHEMBL133836 9.89 Ki 0.13 Preclinical
CHEMBL216640 9.85 Ki 0.14 Preclinical
CHEMBL428669 9.8 Ki 0.16 Preclinical
CHEMBL140050 9.74 Ki 0.18 Clinical
CHEMBL438781 9.7 Ki 0.2 Preclinical
Distribution

pChEMBL Value Distribution

32
5.0
27
5.5
42
6.0
40
6.5
50
7.0
57
7.5
45
8.0
38
8.5
40
9.0
20
9.5
pChEMBL
Approved Drugs

Approved Drugs

NALFURAFINE
CHEMBL267495
Approved 2009
Properties Compare Identifier
NALTREXONE
CHEMBL19019
Approved 1984
Properties Compare Identifier
MORPHINE
CHEMBL70
Approved 1984
Properties Compare Identifier
NALOXONE
CHEMBL80
Approved 1971
Properties Compare Identifier
OXYMORPHONE
CHEMBL963
Approved 1959
Properties Compare Identifier
Assay Landscape

Assay Landscape

173
Total Assays
319
Tested Compounds
2
Assay Types
Binding — 150 assays, 319 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 84 164 7.9
single protein format 31 33 7.1
assay format 13 30 6.6
cell membrane format 13 60 6.4
tissue-based format 9 32 6.8
Functional — 23 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 27 7.8
organism-based format 2 0 —
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine