Assay Detail
Binding
CHEMBL755829
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Opioid receptor mu 1 affinity against the receptor site model site 1 (mu1)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 9.25 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80 | NALOXONE | 4.0 | 1 | 9.40 |
| CHEMBL149414 | — | — | 1 | 9.30 |
| CHEMBL340032 | DADLE | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80 | NALOXONE | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL149414 | — | Kd | = | 0.5 | nM | 9.30 |
| CHEMBL340032 | DADLE | Kd | = | 0.9 | nM | 9.05 |