Mu-type opioid receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P33535. Use UniProt P33535 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P33535 as the stable identity anchor, then attach disease evidence before program review.
Mu-type opioid receptor
Review this target as Mu-type opioid receptor, mapped to UniProt P33535. Sequence length is 398 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mu-type opioid receptor as ChEMBL target CHEMBL270, mapped to UniProt P33535. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mu-type opioid receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P33535 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mu-type opioid receptor |
| UniProt Accession | P33535 |
| Component Type | Protein |
| Sequence Length | 398 aa |
Mu-type opioid receptor
Review this target as Mu-type opioid receptor, mapped to UniProt P33535. Sequence length is 398 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1649946 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL254927 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3634251 | 10.92 | Ki | 0.012 | Preclinical |
| CHEMBL4126050 | 10.92 | EC50 | 0.012 | Preclinical |
| CHEMBL4126102 | 10.92 | EC50 | 0.012 | Preclinical |
| CHEMBL4762529 | 10.9 | Ki | 0.0125 | Preclinical |
| CHEMBL2369874 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL2373217 | 10.89 | Ki | 0.013 | Preclinical |
| CHEMBL4745764 | 10.87 | Ki | 0.0136 | Preclinical |
| CHEMBL365983 | 10.85 | Ki | 0.014 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 167 | 1,057 | 7.5 |
| assay format | 121 | 724 | 7.5 |
| single protein format | 96 | 371 | 7.2 |
| cell-based format | 88 | 530 | 8.1 |
| tissue-based format | 77 | 537 | 7.4 |
| subcellular format | 9 | 65 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 102 | 289 | 8.0 |
| cell membrane format | 22 | 47 | 6.3 |
| assay format | 10 | 33 | 7.1 |
| tissue-based format | 5 | 1 | 7.3 |
| single protein format | 2 | 3 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 1 | 4 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 1 | 0 | — |