Kappa-type opioid receptor · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P33534. Use UniProt P33534 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P33534 as the stable identity anchor, then attach disease evidence before program review.
Kappa-type opioid receptor
Review this target as Kappa-type opioid receptor, mapped to UniProt P33534. Sequence length is 380 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Kappa-type opioid receptor as ChEMBL target CHEMBL4329, mapped to UniProt P33534. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Kappa-type opioid receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P33534 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Kappa-type opioid receptor |
| UniProt Accession | P33534 |
| Component Type | Protein |
| Sequence Length | 380 aa |
Kappa-type opioid receptor
Review this target as Kappa-type opioid receptor, mapped to UniProt P33534. Sequence length is 380 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4115374 | 10.92 | EC50 | 0.012 | Preclinical |
| CHEMBL489866 | 10.72 | IC50 | 0.019 | Preclinical |
| CHEMBL4115212 | 10.71 | EC50 | 0.0194 | Preclinical |
| CHEMBL4112945 | 10.68 | EC50 | 0.021 | Preclinical |
| CHEMBL4112470 | 10.67 | EC50 | 0.0216 | Preclinical |
| CHEMBL4112000 | 10.63 | EC50 | 0.0234 | Preclinical |
| CHEMBL4113007 | 10.55 | EC50 | 0.028 | Preclinical |
| CHEMBL1795711 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL4108145 | 10.5 | EC50 | 0.0314 | Preclinical |
| CHEMBL4108041 | 10.49 | EC50 | 0.032 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 41 | 12 | 8.0 |
| cell-based format | 34 | 81 | 7.3 |
| tissue-based format | 21 | 41 | 8.6 |
| assay format | 19 | 39 | 9.8 |
| organism-based format | 8 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 54 | 129 | 8.0 |
| single protein format | 20 | 78 | 7.5 |
| cell-based format | 10 | 116 | 8.3 |
| tissue-based format | 9 | 10 | 6.9 |
| assay format | 4 | 28 | 7.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 25 | 9.0 |