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Target Snapshot

CHEMBL3222 Target Snapshot

Delta-type opioid receptor · SINGLE PROTEIN · Mus musculus

2,054Compounds
565Assays
11Approved Drugs
2,017.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P32300. Use UniProt P32300 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P32300 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Delta-type opioid receptor as ChEMBL target CHEMBL3222, mapped to UniProt P32300. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Delta-type opioid receptor
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL3222
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P32300
Delta-type opioid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Delta-type opioid receptor is the right protein anchor across sources, using UniProt P32300 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDelta-type opioid receptor
UniProt AccessionP32300
Component TypeProtein
Sequence Length372 aa

Delta-type opioid receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Delta-type opioid receptor, mapped to UniProt P32300. Sequence length is 372 aa.

Mapped IDP32300
Review nameDelta-type opioid receptor
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

11
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC501,093.0
KI705.0
EC5054.0
KD165.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL196774 10.99 Kd 0.01023 Preclinical
CHEMBL373192 10.97 Kd 0.01072 Preclinical
CHEMBL607401 10.82 IC50 0.015 Preclinical
CHEMBL339320 10.8 IC50 0.016 Preclinical
CHEMBL129252 10.8 IC50 0.016 Preclinical
CHEMBL198800 10.73 Kd 0.01862 Preclinical
CHEMBL3758292 10.7 EC50 0.01995 Preclinical
CHEMBL204136 10.7 IC50 0.01995 Preclinical
CHEMBL169860 10.66 IC50 0.022 Preclinical
CHEMBL197185 10.62 Kd 0.02399 Preclinical
Distribution

pChEMBL Value Distribution

58
5.0
87
5.5
161
6.0
170
6.5
216
7.0
216
7.5
226
8.0
202
8.5
167
9.0
106
9.5
pChEMBL
Approved Drugs

Approved Drugs

NALFURAFINE
CHEMBL267495
Approved 2009
NALFURAFINE HYDROCHLORIDE
CHEMBL490665
Approved 2009
NALTREXONE
CHEMBL19019
Approved 1984
MORPHINE
CHEMBL70
Approved 1984
NALOXONE
CHEMBL80
Approved 1971
FENTANYL
CHEMBL596
Approved 1968
FENTANYL CITRATE
CHEMBL688
Approved 1968
OXYMORPHONE
CHEMBL963
Approved 1959
Assay Landscape

Assay Landscape

565
Total Assays
884
Tested Compounds
3
Assay Types
Functional — 344 assays, 633 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 178 431 7.7
assay format 132 149 8.0
cell-based format 17 53 7.1
organism-based format 14 0
cell membrane format 3 0
Binding — 220 assays, 884 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 103 254 7.7
tissue-based format 46 193 7.7
cell-based format 34 181 7.2
cell membrane format 19 123 7.9
assay format 17 133 8.3
organism-based format 1 0
ADME — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 7.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine