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Target Snapshot

CHEMBL269 Target Snapshot

Delta-type opioid receptor · SINGLE PROTEIN · Rattus norvegicus

2,704Compounds
538Assays
14Approved Drugs
3,306.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P33533. Use UniProt P33533 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P33533 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Delta-type opioid receptor as ChEMBL target CHEMBL269, mapped to UniProt P33533. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Delta-type opioid receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL269
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P33533
Delta-type opioid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Delta-type opioid receptor is the right protein anchor across sources, using UniProt P33533 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDelta-type opioid receptor
UniProt AccessionP33533
Component TypeProtein
Sequence Length372 aa

Delta-type opioid receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Delta-type opioid receptor, mapped to UniProt P33533. Sequence length is 372 aa.

Mapped IDP33533
Review nameDelta-type opioid receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

14
Approved
1
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50549.0
KI2,553.0
EC50167.0
KD37.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2115493 11.0 IC50 0.01 Preclinical
CHEMBL2114469 11.0 IC50 0.01 Preclinical
CHEMBL175116 10.74 Ki 0.018 Preclinical
CHEMBL270984 10.72 Ki 0.019 Preclinical
CHEMBL354966 10.68 Ki 0.021 Preclinical
CHEMBL607480 10.68 Ki 0.021 Preclinical
CHEMBL571492 10.66 Ki 0.022 Preclinical
CHEMBL426776 10.55 Ki 0.028 Preclinical
CHEMBL433978 10.52 Ki 0.03 Preclinical
CHEMBL100480 10.51 Ki 0.031 Preclinical
Distribution

pChEMBL Value Distribution

165
5.0
190
5.5
285
6.0
315
6.5
309
7.0
287
7.5
375
8.0
298
8.5
221
9.0
143
9.5
pChEMBL
Approved Drugs

Approved Drugs

ELUXADOLINE
CHEMBL2159122
Approved 2015
NALFURAFINE
CHEMBL267495
Approved 2009
NALMEFENE
CHEMBL982
Approved 1995
MORPHINE
CHEMBL70
Approved 1984
NALTREXONE
CHEMBL19019
Approved 1984
BUPRENORPHINE
CHEMBL511142
Approved 1981
LOPERAMIDE
CHEMBL841
Approved 1976
NALOXONE
CHEMBL80
Approved 1971
FENTANYL
CHEMBL596
Approved 1968
OXYMORPHONE
CHEMBL963
Approved 1959
OXYCODONE
CHEMBL656
Approved 1950
Assay Landscape

Assay Landscape

538
Total Assays
2,245
Tested Compounds
4
Assay Types
Binding — 453 assays, 2,245 compounds
BAO Format Assays Compounds Avg pChEMBL
cell membrane format 148 815 7.4
single protein format 108 235 7.8
assay format 86 666 7.7
tissue-based format 58 241 7.1
cell-based format 44 223 7.9
subcellular format 9 65 8.3
Functional — 82 assays, 84 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 44 67 7.6
assay format 23 1 9.3
cell membrane format 9 13 6.3
tissue-based format 6 3 7.8
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell membrane format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine