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Evidence Snapshot

Delta-type opioid receptor

CHEMBL269 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:09Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL269
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Delta-type opioid receptor as ChEMBL target CHEMBL269, mapped to UniProt P33533. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Delta-type opioid receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL269
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P33533
Delta-type opioid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Delta-type opioid receptor matters

As of 2026-09-14

Delta-type opioid receptor is reviewed as Delta-type opioid receptor (UniProt P33533); the current evidence base includes 14 approved drugs, 2704 compounds, and 538 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 14 approved drugs, 2704 compounds, and 538 assays for this target. The dominant activity type is KI. CHEMBL2114469 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL2114469 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
14 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Delta-type opioid receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P33533, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2704
Total Compounds
538
Total Assays
14
Approved Drugs
IC50: 549.0, KI: 2553.0, EC50: 167.0, KD: 37.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL2114469
 11.0 IC50 —
No preferred name
CHEMBL2115493
 11.0 IC50 —
No preferred name
CHEMBL175116
 10.7 Ki —
No preferred name
CHEMBL270984
 10.7 Ki —
No preferred name
CHEMBL354966
 10.7 Ki —

Approved Drugs

Structure Compound First Approval
ELUXADOLINE
CHEMBL2159122
 2015
NALFURAFINE
CHEMBL267495
 2009
NALMEFENE
CHEMBL982
 1995
MORPHINE
CHEMBL70
 1984
NALTREXONE
CHEMBL19019
 1984
BUPRENORPHINE
CHEMBL511142
 1981
LOPERAMIDE
CHEMBL841
 1976
NALOXONE
CHEMBL80
 1971
FENTANYL
CHEMBL596
 1968
OXYMORPHONE
CHEMBL963
 1959
OXYCODONE
CHEMBL656
 1950
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:09Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL269