Assay Detail
Binding
CHEMBL747922
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In vivo binding affinity against mu opioid receptor was measured by using labeled ligand [3H]naloxone (0.5 nM)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.30 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106027 | — | — | 1 | 9.60 |
| CHEMBL104042 | — | — | 1 | 9.24 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.96 |
| CHEMBL319236 | — | — | 1 | 8.85 |
| CHEMBL323281 | — | — | 1 | 8.41 |
| CHEMBL324418 | — | — | 1 | 8.11 |
| CHEMBL106910 | — | — | 1 | 7.72 |
| CHEMBL106085 | — | — | 1 | 7.54 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.42 |
| CHEMBL321289 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106027 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL104042 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL80 | NALOXONE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL319236 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL323281 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL324418 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL106910 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL106085 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL70 | MORPHINE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL321289 | — | Ki | = | 76.0 | nM | 7.12 |