Kappa-type opioid receptor · SINGLE PROTEIN · Cavia porcellus
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As of 2026-09-13Protein identity stays anchored to UniProt P41144. Use UniProt P41144 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P41144 as the stable identity anchor, then attach disease evidence before program review.
Kappa-type opioid receptor
Review this target as Kappa-type opioid receptor, mapped to UniProt P41144. Sequence length is 380 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Kappa-type opioid receptor as ChEMBL target CHEMBL3952, mapped to UniProt P41144. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Kappa-type opioid receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
| UniProt | P41144 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Kappa-type opioid receptor |
| UniProt Accession | P41144 |
| Component Type | Protein |
| Sequence Length | 380 aa |
Kappa-type opioid receptor
Review this target as Kappa-type opioid receptor, mapped to UniProt P41144. Sequence length is 380 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4077003 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL425806 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL442323 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL415247 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL51204 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL266717 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL266515 | 10.68 | Ki | 0.021 | Preclinical |
| CHEMBL4751305 | 10.66 | Ki | 0.022 | Preclinical |
| CHEMBL415330 | 10.64 | Ki | 0.023 | Preclinical |
| CHEMBL438741 | 10.62 | Ki | 0.024 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 263 | 623 | 7.4 |
| cell membrane format | 163 | 719 | 7.6 |
| assay format | 88 | 470 | 7.4 |
| tissue-based format | 68 | 290 | 7.8 |
| cell-based format | 8 | 264 | 7.4 |
| organism-based format | 7 | 13 | 7.5 |
| cell-free format | 1 | 13 | 7.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 60 | 39 | 7.4 |
| tissue-based format | 52 | 19 | 7.9 |
| cell membrane format | 20 | 23 | 7.1 |
| cell-based format | 1 | 0 | — |