Assay Detail
Binding
CHEMBL917909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from human opioid gamma receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.38 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301160 | BUTORPHAN | — | 1 | 9.64 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.64 |
| CHEMBL224014 | — | — | 1 | 9.54 |
| CHEMBL2113275 | — | — | 1 | 9.37 |
| CHEMBL224671 | — | — | 1 | 9.34 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 9.10 |
| CHEMBL895 | NALBUPHINE | 4.0 | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL224014 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL2113275 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL224671 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL80 | NALOXONE | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL895 | NALBUPHINE | Ki | = | 0.89 | nM | 9.05 |