Compound Detail
CHEMBL923
RISEDRONIC ACID 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL923 |
| Name | RISEDRONIC ACID |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | IIDJRNMFWXDHID-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
23
Targets
94
Activities
3
Assay Types
8
PK Parameters
20
Publications
6
Known Names
13
Indications
Molecular Properties
283.1
MW (Da)
-0.37
ALogP
4
HBA
5
HBD
148.2
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1998 |
| Availability | Prescription |
| Chirality | Achiral |
Indications
Bone Diseases Back Pain Bone Diseases, Metabolic Osteitis Deformans Osteoporosis Osteoporosis, Postmenopausal Prostatic Neoplasms Prostatic Neoplasms, Castration-Resistant Spinal Cord Injuries Fibrous Dysplasia of Bone Lung Neoplasms Menopause Chronic Kidney Disease-Mineral and Bone Disorder
ATC Classification
M05BA07
risedronic acid
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: DRUGS FOR TREATMENT OF BONE DISEASES
Activity Summary
IC50 78 meas. best 9.44
Ki 9 meas. best 9.44
EC50 7 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Farnesyl pyrophosphate synthase CHEMBL1782 | Ki | 9.44 | 8.1067 | 0.4 | 3 |
| Farnesyl pyrophosphate synthase CHEMBL1782 | IC50 | 9.44 | 7.6957 | 0.4 | 21 |
| Farnesyl pyrophosphate synthase CHEMBL2150832 | Ki | 7.8 | 7.8 | 16.0 | 1 |
| Farnesyl pyrophosphate synthase CHEMBL3693 | Ki | 7.77 | 7.77 | 17.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.57 | 6.19 | 27.0 | 11 |
| Farnesyl diphosphate synthase CHEMBL4752 | IC50 | 7.57 | 7.57 | 27.0 | 2 |
| Farnesyl diphosphate synthase CHEMBL5831 | IC50 | 7.13 | 7.13 | 74.0 | 3 |
| Butyrophilin subfamily 3 member A1 CHEMBL4105758 | EC50 | 7.1 | 7.1 | 80.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 7.1 | 6.2 | 80.0 | 2 |
| Farnesyl pyrophosphate synthase CHEMBL3693 | IC50 | 6.77 | 6.77 | 169.8 | 3 |
| Mus musculus CHEMBL375 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Toxoplasma gondii CHEMBL612888 | IC50 | 6.31 | 6.31 | 490.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 5.92 | 5.885 | 1200.0 | 2 |
| Leishmania donovani CHEMBL367 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
| HFF CHEMBL614071 | IC50 | 5.62 | 5.62 | 2400.0 | 1 |
| Toxoplasma gondii CHEMBL612888 | EC50 | 5.62 | 5.62 | 2400.0 | 1 |
| Dictyostelium discoideum CHEMBL612373 | IC50 | 5.52 | 5.205 | 3000.0 | 4 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 5.38 | 5.1733 | 4120.0 | 3 |
| Trypanosoma brucei CHEMBL612849 | IC50 | 5.07 | 5.07 | 8600.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 5.0 | 4.985 | 10000.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 4.89 | 4.61 | 13000.0 | 3 |
| RPMI-8226 CHEMBL614882 | EC50 | 4.89 | 4.89 | 13000.0 | 1 |
| Plasmodium berghei CHEMBL612653 | IC50 | 4.8 | 4.8 | 16000.0 | 1 |
| SF-268 CHEMBL613977 | IC50 | 4.63 | 4.63 | 23300.0 | 1 |
| ADMET CHEMBL612558 | IC50 | 4.51 | 4.51 | 31000.0 | 1 |
| MCF7 CHEMBL387 | IC50 | 4.45 | 4.45 | 35700.0 | 1 |
| NCI-H460 CHEMBL396 | IC50 | 4.36 | 4.36 | 43700.0 | 1 |
| Entamoeba histolytica CHEMBL612853 | IC50 | 4.13 | 4.13 | 73500.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.5 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.5 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.2 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.5 | mL.min-1.kg-1 | Homo sapiens |
| Fu | 0.76 | - | Homo sapiens |
| Fu | 0.76 | - | Homo sapiens |
| MRT | 70.0 | hr | Homo sapiens |
| T1/2 | 200.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine