Assay Detail
Binding
CHEMBL2156000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.61 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 8.52 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 8.00 |
| CHEMBL53950 | INCADRONIC ACID | 2.0 | 1 | 7.52 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 7.30 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL53950 | INCADRONIC ACID | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 200.0 | nM | 6.70 |