Assay Detail
Binding
CHEMBL839917
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Binding affinity towards Farnesyl diphosphate synthase from leishmania major
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Farnesyl pyrophosphate synthase (CHEMBL3693) ↗| Type | SINGLE PROTEIN |
| Organism | Leishmania donovani |
Publication
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.25 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192342 | — | — | 1 | 8.05 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 7.96 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 7.77 |
| CHEMBL191634 | — | — | 1 | 7.75 |
| CHEMBL373332 | — | — | 1 | 7.70 |
| CHEMBL192043 | — | — | 1 | 7.70 |
| CHEMBL363145 | — | — | 1 | 7.52 |
| CHEMBL193356 | — | — | 1 | 7.42 |
| CHEMBL193722 | — | — | 1 | 7.30 |
| CHEMBL192938 | — | — | 1 | 7.16 |
| CHEMBL193619 | — | — | 1 | 7.12 |
| CHEMBL425896 | — | — | 1 | 7.10 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 7.02 |
| CHEMBL190258 | — | — | 1 | 6.96 |
| CHEMBL363434 | — | — | 1 | 6.80 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | 6.72 |
| CHEMBL193131 | — | — | 1 | 6.42 |
| CHEMBL192017 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192342 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4303669 | ZOLEDRONIC ACID | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL923 | RISEDRONIC ACID | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL191634 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL373332 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL192043 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL363145 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL193356 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL193722 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL192938 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL193619 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL425896 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL870 | ALENDRONIC ACID | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL190258 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL363434 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL834 | PAMIDRONIC ACID | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL193131 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL192017 | — | Ki | = | 950.0 | nM | 6.02 |