Assay Detail
Binding
CHEMBL677586
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Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.05 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 8.00 |
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | 7.70 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 7.30 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | 6.70 |
| CHEMBL293522 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL997 | IBANDRONIC ACID | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL293522 | — | IC50 | = | 2930.0 | nM | 5.53 |