Assay Detail
Binding
CHEMBL2092208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.12 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 7.96 |
| CHEMBL2088336 | — | — | 1 | 7.92 |
| CHEMBL2088339 | — | — | 1 | 7.80 |
| CHEMBL2048241 | — | — | 1 | 7.55 |
| CHEMBL2048238 | — | — | 1 | 7.33 |
| CHEMBL2088338 | — | — | 1 | 7.22 |
| CHEMBL291736 | — | — | 1 | 7.07 |
| CHEMBL2048247 | — | — | 1 | 6.94 |
| CHEMBL2048239 | — | — | 1 | 6.82 |
| CHEMBL2048237 | — | — | 1 | 6.79 |
| CHEMBL2088337 | — | — | 1 | 6.00 |
| CHEMBL2088344 | — | — | 1 | 6.00 |
| CHEMBL2088342 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2088336 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2088339 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2048241 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2048238 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2088338 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL291736 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2048247 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2048239 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2048237 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL2088337 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2088344 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2088342 | — | IC50 | > | 1000.0 | nM | - |