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Assay Detail

CHEMBL5223797

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant FPP synthase expressed in Escherichia coli S100 using FPP and IPP as substrates preincubated for 15 mins followed by substrate addition measured after 60 mins by scintillation counting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Farnesyl pyrophosphate synthase (CHEMBL1782)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Targeting Small GTPases and Their Prenylation in Diabetes Mellitus.
Gendaszewska-Darmach E, Garstka MA, Błażewska KM.
J Med Chem (2021) 64 : 9677 -9710
PubMed 34236862 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 7.02 8.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL923 RISEDRONIC ACID 4.0 1 8.41
CHEMBL870 ALENDRONIC ACID 4.0 1 6.34
CHEMBL834 PAMIDRONIC ACID 4.0 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL923 RISEDRONIC ACID IC50 = 3.9 nM 8.41
CHEMBL870 ALENDRONIC ACID IC50 = 460.0 nM 6.34
CHEMBL834 PAMIDRONIC ACID IC50 = 500.0 nM 6.30