Assay Detail
Binding
CHEMBL2040420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IMPDH in mouse L1210 cells assessed as formation of [2,8-3H]hypoxanthine from [2,8-3H]IMP after 20 to 60 mins
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.50 | 6.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | 4.0 | 2 | 6.00 |
| CHEMBL2036523 | — | — | 1 | 4.00 |
| CHEMBL2036521 | — | — | 1 | 4.00 |
| CHEMBL2036518 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643 | RIBAVIRIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2036523 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2036521 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2036518 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1643 | RIBAVIRIN | Inhibition | - | % | - |