Assay Detail
Binding
CHEMBL1909165
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Cell Type | Reticulocytes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 871 | - | - |
| IC50 | 871 | 5.41 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | 4.0 | 2 | 6.57 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 2 | 6.26 |
| CHEMBL926 | DOBUTAMINE | 4.0 | 2 | 6.22 |
| CHEMBL280998 | CATECHOL | — | 2 | 6.06 |
| CHEMBL418971 | BISPHENOL A | — | 2 | 5.88 |
| CHEMBL456807 | PHENYLHYDRAZINE | — | 2 | 5.78 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 2 | 5.75 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 2 | 5.75 |
| CHEMBL1612004 | — | — | 2 | 5.69 |
| CHEMBL307145 | PYROGALLOL | -1.0 | 2 | 5.67 |
| CHEMBL459 | METHYLDOPA | 4.0 | 2 | 5.67 |
| CHEMBL1009 | LEVODOPA | 4.0 | 2 | 5.65 |
| CHEMBL1714574 | TERCONAZOLE | 4.0 | 2 | 5.61 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 5.56 |
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | — | 2 | 5.54 |
| CHEMBL406 | INDAPAMIDE | 4.0 | 2 | 5.54 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 2 | 5.53 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 2 | 5.53 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 2 | 5.50 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 2 | 5.48 |
| CHEMBL276832 | HYDRALAZINE | 4.0 | 2 | 5.44 |
| CHEMBL32749 | FERULATE | -1.0 | 2 | 5.40 |
| CHEMBL195437 | 4-OCTYLPHENOL | — | 2 | 5.39 |
| CHEMBL828 | PHENOTHIAZINE | 2.0 | 2 | 5.33 |
| CHEMBL1388 | MONOBENZONE | 4.0 | 2 | 5.31 |
| CHEMBL159 | VINBLASTINE | 4.0 | 2 | 5.30 |
| CHEMBL817 | TOLAZAMIDE | 4.0 | 2 | 5.29 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 5.27 |
| CHEMBL691 | ETHINYL ESTRADIOL | 4.0 | 2 | 5.25 |
| CHEMBL141343 | — | — | 2 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506247 | TANNIC ACID | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL926 | DOBUTAMINE | IC50 | = | 599.0 | nM | 6.22 |
| CHEMBL280998 | CATECHOL | IC50 | = | 868.0 | nM | 6.06 |
| CHEMBL418971 | BISPHENOL A | IC50 | = | 1304.0 | nM | 5.88 |
| CHEMBL456807 | PHENYLHYDRAZINE | IC50 | = | 1666.0 | nM | 5.78 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 1785.3 | nM | 5.75 |
| CHEMBL434 | ISOPROTERENOL | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL1612004 | — | IC50 | = | 2048.0 | nM | 5.69 |
| CHEMBL307145 | PYROGALLOL | IC50 | = | 2114.0 | nM | 5.67 |
| CHEMBL459 | METHYLDOPA | IC50 | = | 2126.0 | nM | 5.67 |
| CHEMBL1009 | LEVODOPA | IC50 | = | 2258.0 | nM | 5.65 |
| CHEMBL1714574 | TERCONAZOLE | IC50 | = | 2446.0 | nM | 5.61 |
| CHEMBL715 | OLANZAPINE | IC50 | = | 2768.0 | nM | 5.56 |
| CHEMBL1333512 | N,N'-DIPHENYL-P-PHENYLENEDIAMINE | IC50 | = | 2883.0 | nM | 5.54 |
| CHEMBL406 | INDAPAMIDE | IC50 | = | 2918.0 | nM | 5.54 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 2949.0 | nM | 5.53 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 2963.0 | nM | 5.53 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3187.0 | nM | 5.50 |
| CHEMBL679 | EPINEPHRINE | IC50 | = | 3279.0 | nM | 5.48 |
| CHEMBL276832 | HYDRALAZINE | IC50 | = | 3649.0 | nM | 5.44 |
| CHEMBL32749 | FERULATE | IC50 | = | 3975.0 | nM | 5.40 |
| CHEMBL195437 | 4-OCTYLPHENOL | IC50 | = | 4093.0 | nM | 5.39 |
| CHEMBL828 | PHENOTHIAZINE | IC50 | = | 4643.0 | nM | 5.33 |
| CHEMBL1388 | MONOBENZONE | IC50 | = | 4892.0 | nM | 5.31 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5037.0 | nM | 5.30 |
| CHEMBL817 | TOLAZAMIDE | IC50 | = | 5106.0 | nM | 5.29 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 5425.0 | nM | 5.27 |
| CHEMBL691 | ETHINYL ESTRADIOL | IC50 | = | 5678.0 | nM | 5.25 |
| CHEMBL141343 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL1405 | ESTRONE | IC50 | = | 6589.0 | nM | 5.18 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 6956.0 | nM | 5.16 |
| CHEMBL526 | PROPOFOL | IC50 | = | 7596.0 | nM | 5.12 |
| CHEMBL193482 | ESTRIOL | IC50 | = | 8635.0 | nM | 5.06 |
| CHEMBL44 | GENISTEIN | IC50 | = | 9033.0 | nM | 5.04 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 11295.0 | nM | 4.95 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 13590.0 | nM | 4.87 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 13797.0 | nM | 4.86 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 15101.0 | nM | 4.82 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 15951.0 | nM | 4.80 |
| CHEMBL964 | DISULFIRAM | IC50 | = | 16066.0 | nM | 4.79 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 16159.0 | nM | 4.79 |
| CHEMBL112 | ACETAMINOPHEN | IC50 | = | 28380.0 | nM | 4.55 |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL313493 | METHANESULFONIC ACID METHYL ESTER | Ki | - | — | - | |
| CHEMBL878 | METOLAZONE | IC50 | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | IC50 | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - |