Compound Detail
CHEMBL828
PHENOTHIAZINE 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL828 |
| Name | PHENOTHIAZINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WJFKNYWRSNBZNX-UHFFFAOYSA-N |
22
Targets
28
Activities
3
Assay Types
0
PK Parameters
20
Publications
9
Known Names
Molecular Properties
199.3
MW (Da)
3.89
ALogP
2
HBA
1
HBD
12.0
PSA (Ų)
0.59
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 18 meas. best 7.8
Ki 7 meas. best 8.37
EC50 3 meas. best 7.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL3602 | Ki | 8.37 | 8.37 | 4.3 | 1 |
| Cytochrome P450 1A2 CHEMBL3356 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| HT-1080 CHEMBL614580 | EC50 | 7.31 | 7.31 | 49.0 | 1 |
| Prostaglandin G/H synthase 1 CHEMBL221 | IC50 | 6.71 | 6.71 | 196.0 | 1 |
| NADPH oxidase 1 CHEMBL1287628 | IC50 | 6.46 | 6.445 | 349.0 | 2 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | IC50 | 6.34 | 6.34 | 461.0 | 1 |
| Sodium-dependent noradrenaline transporter CHEMBL222 | Ki | 6.34 | 6.34 | 457.0 | 1 |
| Prostaglandin G/H synthase 2 CHEMBL230 | IC50 | 6.27 | 6.27 | 532.0 | 1 |
| Amine oxidase [flavin-containing] A CHEMBL1951 | IC50 | 6.23 | 6.23 | 592.0 | 1 |
| Cyclooxygenase CHEMBL2095157 | IC50 | 6.03 | 6.03 | 940.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 5.93 | 5.93 | 1171.0 | 1 |
| U-937 CHEMBL612794 | IC50 | 5.86 | 5.86 | 1390.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 5.83 | 5.83 | 1465.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | IC50 | 5.65 | 5.65 | 2236.0 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 CHEMBL4358 | IC50 | 5.33 | 5.33 | 4643.0 | 1 |
| Cholinesterase CHEMBL1914 | IC50 | 5.24 | 5.24 | 5800.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 5.22 | 5.22 | 6000.0 | 1 |
| Acetylcholinesterase CHEMBL220 | IC50 | 5.14 | 5.14 | 7300.0 | 1 |
| Adenosine receptor A3 CHEMBL256 | Ki | 4.84 | 4.84 | 14492.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 4.83 | 4.83 | 14807.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | IC50 | 4.73 | 4.73 | 18636.0 | 1 |
| Cannabinoid receptor 1 CHEMBL218 | Ki | 4.71 | 4.71 | 19624.0 | 1 |
| Cannabinoid receptor 1 CHEMBL218 | IC50 | 4.61 | 4.61 | 24857.0 | 1 |
| Adenosine receptor A3 CHEMBL256 | IC50 | 4.59 | 4.59 | 25640.0 | 1 |
| ADMET CHEMBL612558 | EC50 | 4.58 | 4.58 | 26000.0 | 1 |
| Alpha-synuclein CHEMBL6152 | IC50 | 4.58 | 4.58 | 26000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine