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Assay Detail

CHEMBL1614384

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1). (Class of assay: confirmatory) [Related pubchem assays: 2532 (Dose response (NOX1 inhibitors, HEK/293 cells)), 1792 (Primary Screen (NOX1 inhibitors)), 1796 (Summary AID (NOX1 inhibitors)), 2545 (Confirmation screen (NOX1 inhibitors, HEK/293 cells)), 2539 (Counterscreen (NOX2, NOX3, NOX4 inhibitors)), 2541 (Confirmation screen (NOX1 inhibitors)), 1823 (Counterscreen (luminal))]
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NADPH oxidase 1 (CHEMBL1287628)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.61 7.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1323615 1 7.36
CHEMBL1567692 1 7.32
CHEMBL1331532 1 7.28
CHEMBL1401860 1 7.27
CHEMBL1350157 1 7.08
CHEMBL407734 1 6.81
CHEMBL1449547 1 6.81
CHEMBL1377821 1 6.75
CHEMBL1330018 1 6.73
CHEMBL1526463 1 6.60
CHEMBL828 PHENOTHIAZINE 2.0 1 6.46
CHEMBL1404241 1 6.45
CHEMBL1331887 1 6.33
CHEMBL1362864 1 6.00
CHEMBL1437772 1 5.34
CHEMBL1334632 1 5.18
CHEMBL1515783 1 -
CHEMBL1331821 1 -
CHEMBL1357284 1 -
CHEMBL1329357 1 -
CHEMBL1408592 1 -
CHEMBL1396515 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1323615 IC50 = 44.0 nM 7.36
CHEMBL1567692 IC50 = 48.0 nM 7.32
CHEMBL1331532 IC50 = 53.0 nM 7.28
CHEMBL1401860 IC50 = 54.0 nM 7.27
CHEMBL1350157 IC50 = 83.0 nM 7.08
CHEMBL407734 IC50 = 156.0 nM 6.81
CHEMBL1449547 IC50 = 156.0 nM 6.81
CHEMBL1377821 IC50 = 176.0 nM 6.75
CHEMBL1330018 IC50 = 187.0 nM 6.73
CHEMBL1526463 IC50 = 252.0 nM 6.60
CHEMBL828 PHENOTHIAZINE IC50 = 349.0 nM 6.46
CHEMBL1404241 IC50 = 354.0 nM 6.45
CHEMBL1331887 IC50 = 464.0 nM 6.33
CHEMBL1362864 IC50 = 1000.0 nM 6.00
CHEMBL1437772 IC50 = 4570.0 nM 5.34
CHEMBL1334632 IC50 = 6603.0 nM 5.18
CHEMBL1515783 IC50 > 20000.0 nM -
CHEMBL1331821 IC50 > 20000.0 nM -
CHEMBL1357284 IC50 > 20000.0 nM -
CHEMBL1329357 IC50 > 20000.0 nM -
CHEMBL1408592 IC50 > 20000.0 nM -
CHEMBL1396515 IC50 > 20000.0 nM -