Compound Detail
CHEMBL1526463
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Basic Information
| ChEMBL ID | CHEMBL1526463 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IJAMPUSKECGEIE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
325.4
MW (Da)
4.38
ALogP
3
HBA
2
HBD
61.4
PSA (Ų)
0.77
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NADPH oxidase 1 CHEMBL1287628 | IC50 | 6.6 | 6.6 | 252.0 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | IC50 | 5.35 | 5.35 | 4483.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NADPH oxidase 1 | IC50 | = | 252.0 | nM | 6.6 | PUBCHEM_BIOASSAY: Luminescence-based cell-based dose response assay to identify ... | - |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | IC50 | = | 4483.57 | nM | 5.35 | PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibito... | - |
Data from ChEMBL 36 via Core Engine