Assay Detail
Binding
CHEMBL619928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of 5-lipoxygenase pathway in rat basophilic leukemia (RBL-1) cells
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 5.65 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64404 | — | — | 1 | 7.70 |
| CHEMBL62772 | — | — | 1 | 7.00 |
| CHEMBL64337 | — | — | 1 | 6.52 |
| CHEMBL64763 | — | — | 1 | 6.52 |
| CHEMBL302879 | — | — | 1 | 6.52 |
| CHEMBL276850 | PHENOXAZINE | — | 1 | 6.50 |
| CHEMBL64051 | — | — | 1 | 6.40 |
| CHEMBL60994 | — | — | 1 | 6.40 |
| CHEMBL63546 | — | — | 1 | 6.30 |
| CHEMBL64422 | — | — | 1 | 6.30 |
| CHEMBL61952 | — | — | 1 | 6.22 |
| CHEMBL64490 | — | — | 1 | 6.22 |
| CHEMBL64858 | — | — | 1 | 6.16 |
| CHEMBL304698 | — | — | 1 | 6.16 |
| CHEMBL64064 | — | — | 1 | 6.16 |
| CHEMBL60136 | — | — | 1 | 6.10 |
| CHEMBL292884 | — | — | 1 | 6.10 |
| CHEMBL62572 | — | — | 1 | 6.05 |
| CHEMBL64370 | — | — | 1 | 6.05 |
| CHEMBL62693 | — | — | 1 | 6.00 |
| CHEMBL64396 | — | — | 1 | 5.96 |
| CHEMBL62617 | — | — | 1 | 5.92 |
| CHEMBL444828 | — | — | 1 | 5.92 |
| CHEMBL293617 | — | — | 1 | 5.89 |
| CHEMBL62616 | — | — | 1 | 5.89 |
| CHEMBL60499 | — | — | 1 | 5.85 |
| CHEMBL292324 | — | — | 1 | 5.85 |
| CHEMBL828 | PHENOTHIAZINE | 2.0 | 1 | 5.85 |
| CHEMBL61422 | — | — | 1 | 5.82 |
| CHEMBL304205 | ACRIDAN | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64404 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL62772 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL64337 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL64763 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL302879 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL276850 | PHENOXAZINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL64051 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL60994 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL63546 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL64422 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL61952 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL64490 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL304698 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL64064 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL64858 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL60136 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL292884 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL62572 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL64370 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL62693 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL64396 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL62617 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL444828 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL293617 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL62616 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL60499 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL828 | PHENOTHIAZINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL292324 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL61422 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL304205 | ACRIDAN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL60790 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL62101 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL304647 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL418665 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL64738 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL64435 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL61065 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL64403 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL62916 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL417557 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL59748 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL64399 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL304663 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL64458 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL302414 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL304690 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL302394 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL293910 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1908355 | TENIDAP | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL293858 | — | IC50 | = | 9000.0 | nM | 5.05 |