Compound Detail
CHEMBL276850
PHENOXAZINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL276850 |
| Name | PHENOXAZINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TZMSYXZUNZXBOL-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
183.2
MW (Da)
3.54
ALogP
2
HBA
1
HBD
21.3
PSA (Ų)
0.58
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL215 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
| Cyclooxygenase CHEMBL2095157 | IC50 | 6.46 | 6.46 | 350.0 | 1 |
| U-937 CHEMBL612794 | IC50 | 4.84 | 4.84 | 14500.0 | 1 |
| K562 CHEMBL385 | IC50 | 4.78 | 4.78 | 16800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 20.0 | nM | 7.7 | Inhibition of [14C]arachidonic acid conversion to 5-HETE by broken cell 5-lipoxy... | - |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 320.0 | nM | 6.5 | In vitro inhibition of 5-lipoxygenase pathway in rat basophilic leukemia (RBL-1)... | 2113951 |
| Cyclooxygenase | IC50 | = | 350.0 | nM | 6.46 | In vitro inhibition of Prostaglandin G/H synthase pathway in rat basophilic leuk... | 2113951 |
| U-937 | IC50 | = | 14500.0 | nM | 4.84 | Cytotoxicity in UV-irradiated human U937 cells exposed to photosensitizer for 2 ... | 24900465 |
| K562 | IC50 | = | 16800.0 | nM | 4.78 | Antiproliferative activity against human K562 cells after 48 hrs by Alamar blue ... | 28045256 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17236778 | 10.1016/j.bmc.2007.01.007 | Erythrocyte | 10 |
| - | 10.1016/S0960-894X(00)80241-3 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| - | 10.1016/S0960-894X(00)80241-3 | Oryctolagus cuniculus | 1 |
| 2113951 | 10.1021/jm00169a035 | Cyclooxygenase | 1 |
| 2113951 | 10.1021/jm00169a035 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| 19056282 | 10.1016/j.bmc.2008.11.040 | ADMET | 1 |
| 21563750 | 10.1021/jm200436t | K562 | 1 |
| 21563750 | 10.1021/jm200436t | Tubulin | 1 |
| 24900465 | 10.1021/ml200266v | U-937 | 1 |
| - | 10.1039/C3MD00397C | HepG2 | 1 |
| 28045256 | 10.1021/acs.jmedchem.6b01591 | K562 | 1 |
| 28045256 | 10.1021/acs.jmedchem.6b01591 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine