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Assay Detail

CHEMBL2065463

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity in UV-irradiated human U937 cells exposed to photosensitizer for 2 hrs before irradiation for 20 mins by WST-1 assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-937
Confidence 1 — Organism
Curated By Autocuration

Target

U-937 (CHEMBL612794)
Type CELL-LINE
Organism Homo sapiens

Publication

Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines.
Rajagopalan R, Lin TS, Karwa AS, Poreddy AR, Asmelash B, Dorshow RB.
ACS Med Chem Lett (2012) 3 : 284 -288
PubMed 24900465 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.75 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2062587 1 6.77
CHEMBL304205 ACRIDAN 1 6.17
CHEMBL828 PHENOTHIAZINE 2.0 1 5.86
CHEMBL243596 IMINOSTILBENE 1 5.59
CHEMBL243580 CARBAZOLE 1 5.25
CHEMBL276850 PHENOXAZINE 1 4.84
CHEMBL2062589 1 -
CHEMBL63054 1 -
CHEMBL2062588 1 -
CHEMBL436589 ACRIDONE 1 -
CHEMBL2062586 DIHYDROPHENANTHRIDINE 1 -
CHEMBL38688 DIPHENYLAMINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2062587 IC50 = 170.0 nM 6.77
CHEMBL304205 ACRIDAN IC50 = 680.0 nM 6.17
CHEMBL828 PHENOTHIAZINE IC50 = 1390.0 nM 5.86
CHEMBL243596 IMINOSTILBENE IC50 = 2580.0 nM 5.59
CHEMBL243580 CARBAZOLE IC50 = 5560.0 nM 5.25
CHEMBL276850 PHENOXAZINE IC50 = 14500.0 nM 4.84
CHEMBL2062589 IC50 - -
CHEMBL63054 IC50 - -
CHEMBL2062588 IC50 - -
CHEMBL436589 ACRIDONE IC50 - -
CHEMBL2062586 DIHYDROPHENANTHRIDINE IC50 - -
CHEMBL38688 DIPHENYLAMINE IC50 - -